枸杞多糖对大鼠性器官及血清性激素水平的影响

Effect of lycium barbarum polysaccharides on rats′ sexual organ indexes and serum sexual hormone levels

目的:探讨枸杞多糖(LBP)对不同性别、不同月龄大鼠性激素和性器官的影响。方法:23只SD雌性成年大鼠(15月龄)、20只雌性幼年大鼠(1.5月龄)及19只雄性青年大鼠(5.5月龄),按给予枸杞多糖的不同剂量分别分为4组、2组和4组,灌胃给药,两周后测定大鼠性激素水平及性器官脏器系数。结果:LBP对雌性成年大鼠子宫和卵巢有增重趋势,200 mg/kg剂量组效果较好;对雌性幼年大鼠子宫和卵巢有显著增重作用;对雄性大鼠提肛肌具有显著增重作用,100 mg/kg剂量组增重作用更明显。LBP各给药组T,E2有下降趋势,但无统计学差异,可能属正常波动范围。结论:LBP对大鼠性器官有增重作用,对性激素在正常范围内维持在较低水平,其机制可能是通过增加受体表达和敏感性发挥效应。

Objective： To investigate the effect of Lycium barbarum Polysaccharides （LBP） on rats of different months and different sex. Methods： Twenty three SD female rats （15 months）,20 female rats （1.5 months） and 19 male rats （5.5 months） were divided into four, two and four groups according to their different doses of LBP. And the drug was poured into the rats＇ stomach. Serum sexual hormone levels and sexual organ indexes were measured after two weeks. Results： Taken LBP two weeks later, the weight of uteruses and ovaries of female rats（ 15 months） were elevateci; the weight of uteruses and ovaries of female rats（ 1.5 months） were increased remarkably; the weight of muscle levafing anus of male rats（5.5 months） were increased remarkably. While the serum sex hormones of all the groups shown a lower level at normal ranges. Conclusion： LBP could elevate sexual organ index and keep a lower serum sex hormones level at the normal ranges, and further implied that LBP might exert the effects by affecting the sex hormone receptor.