中药缓控释微丸制剂的研究进展

Advances of sustained/controlled release pellets in traditional Chinese medicine

微丸作为一种多单元释药系统,具有流动性好,释药稳定、可靠、均匀等特点。随着现代制备工艺的逐渐成熟及辅料的发展,微丸在缓控释制剂中的应用备受瞩目。作者对中药缓控释微丸制剂释药机制、制备方法、辅料及其体内过程等方面的研究进行了综述,旨在为研究开发中药口服缓控释制剂提供思路和方法。

Pellets are multiple-unit drug delivery system, which have good fluidity, release stability and uniformity. With preparation techniques and excipient materials gradually established, pellets play an important part in the development of sustained/ controlled release drug delivery system. The recent advances in pellets including the release mechanism, preparation methods, excipients and the characteristics in vivo for the sustained/controlled release pellets in traditional Chinese medicine （TCM） were reviewed in order to provide the strategies and rational methods for further investigations and applications.