Ⅳ型胶原酶在胃癌浸润转移中的作用

The influence of type Ⅳ collagenase on invasion and metastasis in gastric carcinoma

应用免疫组化技术研究４６例胃癌手术切除新鲜标本及其引流区域淋巴结中Ⅳ型胶原酶的表达，以探索其在胃癌浸润转移中的作用。结果发现：Ⅳ型胶原酶存在于正常胃小凹上皮和胃癌中，但在５７％（２６／４６）胃癌中的表达增强（Ｐ＜０．０１），而且在有些胃癌组织浸润前缘其表达增强，在胃癌原发灶中Ⅳ型胶原酶的表达和淋巴结转移灶中的表达一致。另外，在有淋巴结转移的胃癌原发灶中，Ⅳ型胶原酶的表达较无淋巴结转移的胃癌原发灶中的表达明显增强（Ｐ＜０．０１）．实验表明，Ⅳ型胶原酶可能与胃癌浸润转移密切相关，它可以作为判断胃癌浸润转移恶性表型的有用生物学标志。

In exploring the mechanism of invasion and metastasis in gastric carcinoma, the expression of type Ⅳ collagenase in fresh surgical specimens with regional lymph nodes obtained from gastrectomy was studied immunohistochemically in 46 such cases. The results showed that the expression of type IV collagenase was found both in normal foveolar epithelial cells and gastric carcinoma cells, but was enhanced on 57% (26/46) gastric carcinoma (p<0. 01). Nevertheless markedly strong staining was found at the front edge of invasive carcinoma. Its expression in primary gastric carcinoma corresponds well to that in lymph node metastasis. In addition, its expression in gastric carcinoma with lymph node metastasis was markedly stronger than that without metastasis (p<0. 01 ). The above findings illustrate that type IV collagenase is relevant to the invasion and metastasis in gastric carcinoma.And the molecule might be used as an effective biological marker for malignant phenotype of gastric carcinoma.