皮肤网状组织细胞增生症10例临床病理分析

A clinicopathological analysis of 10 cases with cutaneous reticulohistiocytosis

本文报告分析了１０例皮肤网状组织细胞增生症，包括１例ＭＲ和９例ＲＧ，男女比例３：２，平均发病年龄３５．８岁，皮损表现为暗红色斑、丘疹、结节和萎缩斑，ＭＲ例关节和骨受累。组织病理示真皮内由单核、多核组织细胞浸润，其胞浆丰富呈＂毛玻璃＂样，ＰＡＳ染色阳性。免疫组化示ｌｙｓｏｚｙｍｅ，ＭＡＣ３８５、ｖｉｍｅｎｔｉｎ、α１－ＡＴＴ阳性。对该病临床病理特征、鉴别诊断及病因作讨论分析。

This article reports 10 cases of reticulohistiocytosis,including 1 case of multicentric reticulocytosis (MR) and 9 cases of reticulohistiocytic granuloma (RG). Sex ratio of male to female was 3:2, and the patient's average age was 35. 8 years old. The skin lesions composed of dark reddish patches, papules, nodules and atrophic patches. The joints and the bone also were involved in MR. Histopathologically, the dermis was involved by a large amount of histiocytes, monocytes or multinucleated giant cells that showed abundant eosinophilic, fine granular cytoplasm with a ' ground-glass' appearance. The cytoplasm was strongly PAS Positive. Immunohistochemical studies showed positivity of lysozyme, bone marrow/histiocyte antigen (MAC387),vimentin and α1-an-titrypsin. The clinicopathological features, differential diagnosis and etiology of the disease were also discussed.