初发SLE患者外周血中CD4^+ T细胞表面趋化因子受体的表达及其意义

The expression rate of chemokine receptors on CD4^+ T cells and its pathogenic roles in new-onset systemic lupus erythematosus

目的了解初发系统性红斑狼疮(SLE)外周血CD4+T细胞表面趋化因子受体的表达情况并探讨在发病中的意义。方法流式细胞术检测18例初发SLE患者(有肾炎10例,无肾炎8例)及10例正常对照外周血CD4+T细胞表面趋化因子受体CCR1、CCR3、CCR5的表达情况,比较SLE治疗前后以及正常对照CD4+CCR1+、CD4+CCR3+、CD4+CCR5+T细胞亚群占全部CD4+T细胞比例的差异。结果SLE患者CD4+CCR1+、CD4+CCR5+T细胞亚群百分率显著低于对照组(P均<0.001);CD4+CCR3+T细胞亚群百分率在SLE和对照组间差异无统计学意义。三种T细胞亚群在肾炎组及无肾炎组的差异均不显著(P均>0.05)。CD4+CCR1+T细胞亚群百分率治疗后显著升高(P=0.022);CD4+CCR5+T细胞亚群百分率治疗后升高(1.81±0.95%和2.88±1.42%),但无统计学意义(P=0.065);CD4+CCR3+T细胞亚群百分率治疗后变化无显著性。结论CD4+CCR1+和CD4+CCR5+T细胞亚群可能参与SLE发病机制。

Objective To explore the pathogenic roles of chemkine receptors in systemic lupus erythematosus （SLE） by detecting the expression rate of CCR1,CCR3, CCR5 on CD^ ＋ T cells. Methods The expression rate of CCR1, CCR3, CCR5 on CD^＋ T cells were detected by flow cytometry in 8 new - onset SLE patients （ including 10 cases with nephritis and 8 without nephritis） and 10 normal controls. Results The expression rates of CCR1 and CCR5 on CD^ ＋ T cells in new - onset SLE patients were significantly lower than in controls （P 〈0. 001 ） ;The expression rate of CCR1 ,CCR3 ,CCR5 on CD^ ＋T cells were no different between lupus nephritis group and non -lupus nephritis group ;The expression rate of CCR1 increased significantly after treatment （P = 0.022）, and the expression rate of CCR5 also increased （ but no statistical significance were found. P = 0.065 ）. Conclusion The chemkine receptors （CCR1 and CCRS）maybe act as a important pathogenic role in SLE.