重症肌无力患者外周血、骨髓及胸腺的β-BGT结合蛋白抗体分泌细胞的检测

Antibody-Secreting Cells of β-Bungarotoxin Binding Protein in Peripheral Blood, Bone Marrow and Thymus in Myasthenia Gravis Patients

应用ELISPOT方法检测了12例早期发病行胸腺切除术的重症肌无力(MG)患者的外周血、骨髓和胸腺的β-BGT结合蛋白抗体。结果发现,12例MG病人中,骨髓中的阳性率最高。抗体分泌细胞的数量在半数病例中均以骨髓中为最高,各临床类型MG抗体分泌细胞阳性分布不相一致。结果提示骨髓可能为抗体最早产生的部位,抗体分泌细胞的数量及分布与临床类型无关。

Antibody-secreting cells (ASC) to β-Bungarotoxin binding protein from peripheral blood, bone marrow and thymus were investigated in 12 early engaged myasthenia gravis (MG) patients by ELISPOT assay. We found that there were ASC in all the 3 portions of the body. The positive rates in them were 58% .83. 3% and 66. 7% respectively, and in bone marrow, it was the highest in. half of the patients. There is no relationship between ASC and clinic type. We conclude that ASC to β-Bungarotoxin binding protein may stem from the bone marrow first. Antibody levels do not correlate with clinical status of MG.