摘要
用兔抗人C-erbB-2抗体对133例人胃癌组织进行了免疫组织化学研究,其中24例呈阳性反应(18.1%).结果显示:C-erbB-2表达阳性者有较好的生物学特性.C-erbB-2基因的过度表达是胃癌恶性程度较低的一个指标,术前组织活检测定C-erbB-2的表达情况,有助于判断胃癌的恶性程度,制订手术切除和淋巴结清扫范围.对86例胃癌患者进行了术后5年随访,统计后发现C-erbB—2阳性的病例比阴性病例有较低的近期死亡率和较高的5年生存率,但无显著性差异(P>0.05).C-erbB-2表达与胃癌预后的关系,有待于在更大的病组中作进一步研究.
By using an antibody specific for C-erbB-2 oncogene an im-munohistochemical study of the expression of C-erbB-2 was performed in 133 human gastric cancer specimens. Expression of the protein was detected in 24 cases (18.1%). The results suggested that C-erbB-2 positive cases had better biological behaviors. Preoperative determination of the C-erbB-2 level in biopsy specimens might be useful to estimate the malignant potential of the tumor involved and in planning the treatment for the patient. Follow-up study of 86 gastric patients showed that C-erbB -2 positive cases presented a lower mortality and a higher survival rate than those of C-erbB-2 negative cases, but the difference was not statistically significant (P>0.05). Studies on larger series of patients will be needed for the ultimate verification of the prognostic value of C-erbB-2.
出处
《外科》
1996年第1期25-28,共4页
基金
上海市高教局重点学科基金资助项目
