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钩藤散对D-半乳糖所致衰老模型小鼠相关指标的影响 被引量:2

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摘要 将小鼠随机均分为6组,除正常对照组外,各组每天皮下注射D-半乳糖(0.05 g/kg),连续注射6周。从注射的第7天开始,3个试验组同时灌胃高、中、低剂量的钩藤散浸膏,阳性对照组灌以维生素E(0.05 g/kg),模型对照组与正常对照组每天灌胃等量的蒸馏水,连续给药5周后测定小鼠的训练成绩、记忆成绩及血清超氧化物歧化酶(SOD)、乙酰胆碱酯酶(ACHE)和脑组织丙二醛(MDA)的含量变化。结果显示:3个试验组的训练成绩显著(P<0.05)、记忆成绩极显著(P<0.01)好于模型对照组,血清SOD、ACHE活力极显著(P<0.01)高于模型对照组,脑MDA含量极显著(P<0.01)低于模型组对照组;与正常对照组比,除ACHE偏高外,其余各指标相近。说明钩藤散能提高抗氧化能力,降低自由基含量,增强胆碱能神经系统功能,具有防止衰老的作用。
出处 《畜牧与兽医》 北大核心 2007年第1期44-46,共3页 Animal Husbandry & Veterinary Medicine
基金 江苏省中医药局资助项目(ZY0303)
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