川芎嗪当归治疗肺间质纤维化的实验研究

Using ligustrazini and angelica sinensis treat the bleomycin-induced pulmonary fibrosis in rats

目的为寻找疗效满意,副作用小的中药治疗肺间质纤维化。方法将65只SD大鼠,分为正常组10只及模型组35只(作为对照)。川芎嗪治疗组10只,腹腔内注射川芎嗪。当归治疗组10只,腹腔内注射当归。疗程均为28天。以上各组动物均在28天处死后作病理切片进行光学显微镜组织病理学对照检查,并应用电子计算机图像分析仪进行肺泡炎和肺间质纤维化定量分析,客观地评价药物疗效。结果川芎嗪治疗后肺泡炎及肺纤维化明显减轻,当归次之。结论提示中药川芎嗪、当归治疗肺间质纤维化疗效满意,副作用小,为中药治疗肺纤维化提供了广阔的前景。

Objective To seek a kind of Chinese traditional medicine to treat the bleomycin-induced pulmonary fibrosis. Methods SD rats with bleomycin As induced pulmonary fibrosis, were divided into 4 groups. Normal control group (10 rats), untreated model group (35 rats), ligustrazini group(10 rats), Angelica sinensis group (10 rats). Both ligustrazini and angelica sinensis were given intraperitoneally by injection daily for 28 days. Then all rats were put to death and took out the lungs for examination. Using histopathological examination and image processing computer assisted to evaluate the result of treatments. Results Ligustrazini could obviously reduced alveolitis and fibrosis and Ange- lica sinensis had the similar but lesser result. Conclusion Ligustrazini and angelica sinensis have successful result of treatment for pulmonary fibrosis.