米非司酮、炔诺酮、三苯氧胺对人早孕绒毛鞘糖脂的影响

The Influences of Mifepristone、Norethisterone and Tamoxifen on the Glycosphingolipids Compositions from Human Chorionic Tissues during Early Pregnancy

应用Ｌａｄｉｓｃｈ分离及微量分析方法，对服米非司酮、炔诺酮、三苯氧胺及正常妊娠妇女的绒毛神经节苷脂（Ｇｇ）和中性鞘糖脂（Ｎ－ＧＳＬ）进行定量分析。结果证明，正常及各服药组Ｇｇ和Ｎ－ＧＳＬ组成相同；各服药组Ｇｇ总量比正常组明显减少（Ｐ＜０．０１）。各服药组绒毛ＧＭ３、ＧＭＩ与ＧＤ３、炔诺酮及三苯氧胺组ＧＴｌｂｔｂ正常组均减少（ＰＭＯ．０１和Ｐ＜０．０５）。米非司酮及三苯氧胺组的Ｎ—ＧＳＬ总量均比正常组升高，其中米非司出组织毛ＣＤＨ、ＣＴＨ增加（Ｐ＜０．０５）；而炔诺酮组则ＰＧ升高明显（Ｐ＜０．Ｏ１）。

By using the Ladisch partitioning and microscale- analysis of HPTLC,the comparative quantitative and qualitative studies of Gg and N-GSL compositions from human chorionic villi tissues of normal early pregnant women and women treated with Mifepristone、Norethisterone (NET) and Tamoxifen(TAM)were made in this patterns of Gg and N-GSL in three treated groups were similar to those in the normal pregnant group. The total values of Gg from the chorionic villi tissues were significantly reduced in three treated groups(P<0.01).In all treated groups, the amounts of GM3、GD3 and GMI were conslderably decreased compared with those in normal(P< 0. 01 or P< 0.05).In NET and TAM groups, GT1b was markedly lower than that in normal(P<0. 01).The total values of values of N-GSL exetracted from the chorionic villi tissues were obviously higher in Mifepristone and TAM groups than those in normal(P<0.01).The CDH and CTH were greatly increased in Mifepristone.group as compared with normal (P<0.05).PG in NET group was significantly higher that that in normal (P<0.01).