帕金森病神经保护治疗的困境与思考

Dilemma and Thought of Neuroprotective Therapy for Parkinson's Disease

帕金森病(PD)神经保护策略存在的困惑,是迄今还未找到一种药能确切的保护神经元,推迟发病或延缓疾病的进展。因此,有学者提出“多重靶标治疗神经退行性疾病的多功能药物”的设想。同理,中医复方通过多种有效成分对人体有多环节、多层次、多靶点的整合调节作用,可能对PD神经保护治疗有一定的优势。最后,从现代医学在高度分化的基础上呈现高度综合的发展趋势,对PD的神经保护治疗进行哲学思考并提供方法论。

The existing predicament of neuroprotective strategies for Parkinson＇s disease（ PD） was still unable to find a drug which can exactly protect neurons and delay the onset of disease or postpone morbid progress up to now. Therefore, some scholars raised presumption,that is, ＂Multi- functional drugs for various CNS targets in the treatment of neurodegenerative disorders＂. For the same reason, complex prescription of traditional Chinese medicine should have many superiority in neuroprotective therapy for PD by multiple active substance which had integrative and modulatory effect of multi - link, multistrata, multi - target in human body. It is eventually undertaken philosophical thinking and provides methodology from Modem medicine in the foundation of high differentiation showing high integrative tendency.