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MCM蛋白与肿瘤 被引量：4

MCM Protein and Tumor
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摘要 微小染色体维持蛋白(MCM)是真核生物DNA复制的主要调控因子,在DNA复制的起始和延伸过程中有重要作用,在每个细胞周期中仅发生一次,是标志细胞增殖活性的新指标,对于肿瘤的诊断及预后判断有重要意义。 MCM（minichromoseme maintenance） protein is an essential regulator in the initiation and elongation steps of eukaryotic DNA replication. It is present only once in every cell cycle, and can be regarded as a new parameter of proliferating activity. MCM protein has great importance in the diagnosis and estimation of the prognosis of tumors.
作者 王静 马金龙 王家耀 王强修
机构地区 山东大学山东省立医院病理科
出处 《医学与哲学（B）》 2007年第3期41-42,共2页 Medicine & Philosophy(B)
关键词 MCM蛋白 DNA复制 肿瘤 MCM protein, DNA replication, tumor
分类号 R361.3 [医药卫生—病理学]
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参考文献10

  • 1Mar K C,Ei moto T,Nagaya S,et al.proliferation marker MCM2,but not Ki67,is helpful for distinguishing between mini mally invasive fol-licular carcinoma and follicular adenoma of the thyroid[].Histopathology.2006
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同被引文献55

  • 1任占平.微小染色体维持蛋白与肿瘤[J].诊断病理学杂志,2004,11(6):427-429. 被引量：12
  • 2黄晓平,张旭,苏晓东,马国伟,赵进明,戎铁华.MCM4在食管癌组织中的表达与临床病理的关系[J].癌症,2007,26(1):96-99. 被引量：12
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  • 6Rodins K, Cheale M, Coleman N, et al. Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility. Clin Cancer Res, 2002, 8(4): 1075-1081.
  • 7Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res, 1999, 5(8): 2121-2132.
  • 8Davies R J, Freeman A, Morris LS, et al. Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Cell Sci, 2002, 359 (9321): 1917-1919.
  • 9Yamaguchi H,Osaki T,Kia M,et al.Immune lesponse against cross-reactive epitope on the heat shock protein60 homologic of helicobacter pylori[J].Infect Immun,2000,68(6):3448-3454.
  • 10Lauren P.The two histological main types of gastric carcinoma:diffuse and so-called intestinal-type carcinoma[J].Acta Pathol Microbiol Scand,1965,64(1):31-49.

引证文献4

二级引证文献6

医学与哲学（B）
2007年 第3期

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