不同方式的干预措施对糖耐量受损患者的影响

Effect of intervention measurements of various patterns in patients with impaired glucose tolerance

目的:探讨糖耐量受损患者不同方式干预措施的临床效果。方法:对112例糖耐量受损患者分别采用安慰剂、行为干预、药物、行为干预加药物治疗的措施,均达1年以上,监测人体质量指数、空腹血糖、餐后2 h血糖、糖基化血红蛋白变化。结果:对照组在给予安慰剂治疗1年后,人体质量指数、空腹血糖、餐后2 h血糖、糖基化血红蛋白有上升趋势,但差异无统计学意义(P>0．05);行为干预组及药物治疗组在干预治疗1年后,人体质量指数、空腹血糖、餐后2 h血糖、糖基化血红蛋白等均有不同程度的下降,但差异亦无统计学意义(P>0．05);行为干预加药物治疗组人体质量指数、空腹血糖、餐后2 h血糖、糖基化血红蛋白明显下降,差异有统计学意义(P<0．05)。结论:糖耐量受损患者在控制饮食、坚持体育运动基础上,有必要结合药物干预治疗。

Objective To investigate the clinical effect of various intervention measurements in the patients with impaired glucose tolerance. Methods One hundred and twelve patients with impaired glucose tolerance were randomly divided into 4 groups, intervened with placebo, behavior intervention, drug, both behavior intervention and drug over 1 year respectively. The changes of BMI, fast blood glucose, and 2-hour post-prandial blood glucose and HbAlc were examined. Results The indexes including BMI, fast blood glucose, 2-hour post-prandial blood glucose and HbAlc in control group were higher than before. The indexes in behavior intervention group and drug group were lower after intervention measurements than before, but there was no statistic significant difference（P〉0. 05）. While they were significantly decreased and there was a significant difference in both behavior intervention and drug group after intervention measurements than before（P〈0. 05）. Conclusion Behavior intervention combined with drug therapy will benefit patients with impaired glucose tolerance.