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子癎前期患者血清及脐血sFLT-1水平变化及临床意义 被引量：1

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摘要 子癎前期（preeclampsia，PE）是妊娠期特发性疾病，其发病与胎盘之间存在着密切关系。胎盘缺血、缺氧，产生“某些因子”进入母体血循环，引起血管内皮细胞损伤，导致PE的发生。研究显示可溶性血管内皮生长因子受体-1（soluble fms-like tyrosine kinase 1，sFLT-1）与PE发病关系密切。本文观察了PE患者血清及脐血sFLT-1水平的变化，以探讨sFLT-1与PE发病的关系及其临床意义。
作者 吴维光 曹秀琴 朱淑平
机构地区 天津武警医学院附属医院妇产科
出处 《中华围产医学杂志》 CAS 2007年第2期110-111,共2页 Chinese Journal of Perinatal Medicine
关键词 SFLT-1 临床意义 水平变化 血管内皮生长因子受体 脐血 血清 子癎 血管内皮细胞损伤
分类号 R714 [医药卫生—妇产科学]
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参考文献7

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同被引文献13

  • 1Salahuddin S,Lee Y, Vadnais M, et al. Diagnostic utility of soluble fms-like tyrosine kinase 1 and soluble endoglin in hypertensive diseases of pregnancy. Am J Obstet Gynecol, 2007,197 : 1-6.
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  • 6Xiong Y, Liebermann DA, Tront JS, et al. Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia. J Cell Physiol, 2009,220: 632-639,.
  • 7HildesheimJ, Bulavin DV, Anver MR, et al. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res, 2002,62 : 7305-7315.
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  • 10Bdolah Y, Karumanchi SA, Sachs BP. Recent advances in understanding of preeclampsia. Croat Med J, 2005,46 : 728- 736.

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中华围产医学杂志
2007年 第2期

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