摘要
目的:探讨海洛因依赖者的人格特征与事件相关电位P300的相关性。方法:采用艾森克人格问卷(EPQ)对31例海洛因依赖者和33例正常对照进行人格测定,并用意大利GalileoSirius32导脑诱发电位仪检测事件相关电位P300。结果:与对照组比较,海洛因依赖者E量表分低(t=-2·227,P=0·030);N量表分高(t=2·644,P=0·010);潜伏期N1短(t=-2·113,P=0·039);潜伏期P3长(t=2·453,P=0·017)。海洛因依赖者的P量表与潜伏期P3呈正相关(r=0·302,P=0·049);E量表与潜伏期P2、波幅P2呈负相关(r=-0·358,P=0·024;r=-0·367,P=0·021);N量表与潜伏期N1、N2、波幅P3呈负相关(r=-0·528,P=0·001;r=-0·302,P=0·049;r=-0·328,P=0·036)以及与潜伏期P3呈正相关(r=0·332,P=0·034)。结论:本研究表明海洛因依赖者具有内倾、情绪不稳定、神经质的人格特征,并且与其事件相关电位P300存在一定关联。
Objective： To investigate the correlation between event related potentials P300 and the personality characteristics of heroin dependant patients. Methods ： Thirty one heroin dependent patients （observed group） and 33 normal （control group） were evaluated using Eysenck Personality Questionnaire（EPQ）. The P300 in the observed group and normal group were determined with Galileo Sirius 32 channels evoked potential system. Results： Compared with the control, the E scale scores of EPQ in the observed group were significantly lower （ t = - 2. 227, P = 0. 030 ）, the N scale scores were remarkably higher （ t = 2. 644, P =0. 010） ; the latency N1 was significantly shorter （t = -2. 113, P =0. 039） ; the latency P3 was remarkably longer （t =2. 453, P =0. 017）. The P scale scores of EPQ in heroin dependent patients was positively related to latency P3 （ r = 0. 302, P = 0. 049） ; the E scale scores were negatively related to wave P2 latency and amplitude（r = -0. 358, P =0. 024; r = -0. 367, P =0. 021） ; the N scale scores were negatively related to latency N1, N2, amplitude 173 （ r = - 0. 528, P = 0. 001 ; r = - 0. 302, P = 0. 049 ; r = - 0. 328, P = 0. 036 ） and positively related to latency P3 （ r = 0. 332, P = 0. 034 ）. Conclusion： Heroin dependent patients have introversive, emotional unstable, nervous personality characteristics, which may be related to their subcomponent of event related potentials P300.
出处
《中国药物依赖性杂志》
CAS
CSCD
2006年第6期445-448,共4页
Chinese Journal of Drug Dependence
