80例高血压患者血清胆红素临床分析

Serum Bilirubin Levels of 80 Patients with Essential Hypertension

目的:研究高血压患者血清胆红素与血脂及内皮素之间的关系,探讨它们在高血压发病机制中的相互作用。方法:80例高血压患者和85例健康对照组,都按照体重指数分为两个亚组,常规测量血压、体重、身高,计算体重指数;抽空腹静脉血测其血脂、血清胆红素和内皮素。结果:与健康对照组比较,高血压患者胆红素(P<0.05)水平显著降低,低密度脂蛋白(LDL)和内皮素(ET)明显高于对照组(P<0.05),亚组合并后进行相关分析得到两组总胆红素均与内皮素和LDL呈负相关(P<0.05)。结论:血清胆红素水平与血压之间有一定的相关性,其机制可能是通过LDL和内皮素而实现的。

Objective： To investigate the relations between serum bilirubin level and blood-fat, endothelin in the patients with essential hypertension, and explore their functions in essential hypertension. Methods： Eighty cases with essential hypertension and eighty-five healthy control subjects were divided into two subgroups according to their body mass index. The fasting blood samples were taken for measurements of biochemistry endothelin. Results：Compared with normal control, the hypertension group showed lower （P〈0.05） bilirubin, but higher concentrations of LDL and endothelin（P〈0.05）. Pearson relation analysis showed that bilirubin levels were correlated with endothelin and LDL（P〈0.05） in two complicating groups. Conclusion：There is a significant correlation between the bilirubin and essential hypertension. The results suggest that bilirubin might play regulative roles through LDL-C and endothelin in the development of hypertension.