短期胰岛素泵强化治疗对初发2型糖尿病病人胰岛β细胞功能的影响

The effects of short-term continue subcutaneous insulin injection on β-cell excretive function in newly diagnosed type 2 diabetic patients

目的研究短期持续皮下胰岛素输注(CSII)对初发2型糖尿病病人胰岛β细胞功能的影响。方法初发2型糖尿病患者30例,予以CSII强化治疗2周,治疗前后应用口服葡萄糖耐量试验比较血糖、胰岛素、C肽、ΔI30/ΔG30及Ho-ma-IR的变化。结果CSII强化治疗后空腹及餐后血糖明显下降(P<0.01);胰岛素、C肽释放值均升高(P<0.05);ΔI30/ΔG30升高(P<0.01);Homa-IR降低(P<0.01)。结论短期CSII强化治疗可以使初发2型糖尿病患者胰岛β细胞功能明显改善。

Objective To study the effects of short - term continue subcutaneous insulin injection （CSII） on β - cell function in newly diagnosed type 2 diabetic patients. Methods Chose 30 type 2 diabetic patients who diagnosed newly were treated with glucose tolerance test and insulin excitated test before and after CSII for two weeks. The blood glucose, insulin, C - peptide, △I30/△G30 and Homa - IR were compared. Results After CSII treatment, blood glucose was sign efficiently decreased （P 〈 0.01 ） ; insulin and C -peptide release levels were increased （ P 〈 0.05） ;△I30/△G30 was increased （ P 〈 0.01 ） ; Homa - IR was decreased （ P 〈 0.01 ）. Conclusion Short - term CSII treatment can obviously improve the β - cell function in newly diagnosed type 2 diabetic patients.