还原型谷胱甘肽 甘草酸二铵联合治疗慢性乙型肝炎

Effects of Reduced Glutathione and Glycyrrhizin on Treatment of Chronic Hepatitis B

目的观察还原型谷胱甘肽和甘草酸二铵联合治疗慢性乙型肝炎的临床疗效及其对血清中免疫球蛋白的影响。方法2005年5月-2006年1月间在我院消化内科收住的36例慢性乙型肝炎患者,均同时接受还原型谷胱甘肽和甘草酸二铵静脉治疗,经过14-28d治疗后,抽取患者的外周血,检测患者的各项肝细胞功能指标和各种免疫球蛋白的水平,并评价其临床疗效。结果接受还原型谷胱甘肽和甘利欣治疗结束后,患者的谷丙转氨酶、谷草转氨酶、胆红素均有显著降低（P〈0.05）,临床症状也明显改善。其中8例患者在治疗前后接受肝脏组织活检,发现肝组织炎症细胞浸润也显著降低。而患者血清中的各种免疫球蛋白在治疗前后无明显变化（P〉0.05）。结论联合还原型谷胱甘肽和甘草酸二铵治疗可有效地改善慢性乙型肝炎患者的肝功能异常,控制临床症状的发生,有效地降低促肝细胞炎症变化。

Objective To study the therapeutic effects of reduced glutathione and glycyrrhizin on treatment of chronic hepatitis B, as well as on the levels of serum immunoglobulins. Methods From May 2005 to January 2006, 36 patients with chronic hepatitis B were selected and treated with reduced glutathione and glycyrrhizin. Peripheral blood was taken 14 - 28 days after combined treatment. Hepatic function parameters, immunoglobulins and clinic response were analyzed in these patients. Resuits After combined treatment with reduced glutathione and glycyrrhizin, liver function parameters, e.g. ALT, AST and bilirubin were significantly decreased than those at the beginning of treatment （P 〈 0. 05） . Clinical symptoms were also significantly improved. Liver biopsies were performed in 8 patients before and after combined treatment, and demonstrated a marked decreased lymphocyte infiltration in liver lobules. However, serum immunoglobulins were not significantly changed after combined treatment（ P 〉0. 05）. Conclusion Combined treatment with reduced glutathione and glycyrrhizin is effective to improve clinical symptoms of patients with chronic hepatitis B, control the disease development, improve the clinical symptoms, and down-regulate inflammation in liver tissue.