小家系资料连锁分析参数方法及应用

The linkage analysis of the small pedigree data

目的对于小家系资料通过连锁分析寻找遗传性疾病相关基因。方法运用小家系资料连锁分析参数的方法。结果多位点连锁分析比两位点连锁分析基因定位更精确。结论适用于小家系资料的多位点连锁分析,不仅能算出致病基因与标记的重组率和遗传距离,而且能把致病基因定位至遗传标记的一侧。

Objective To find the loci of human genetic diseases for the small pedigree data through linkage analysis. Methods The parameter linkage analysis of the small pedigree data was used. Results The multipoint linkage analysis could more accurately localize the disease gene than the two-point linkage analysis. Conclusions It suit to the small pedigree data. Multipoint linkage analysis can not only calculate the recombination and map distance, but also localize the disease gene to one side of the marker.