uNTX水平检测的临床意义

Clinical significance of urinary type Ⅰ collagen cross-linked N-telopeptides in bone metastases neoplasm

目的 测定患者尿Ⅰ型胶原交联氨基末端肽（uNTX）水平，评价其与骨转移瘤病情发展和疗效的关系。方法 研究对象分为A、B、C三组。A组为正常成人组；B组为原发肿瘤组；C组为骨转移瘤组。分别检测3组uNTX水平及血清AKP活性和Ca^2＋浓度。C组治疗后10～12周进行uNTX的随访观察。结果 C组uNTX水平显著高于A、B两组，骨转移瘤患者治疗前后uNTX水平也有显著性差异。结论 uNTX水平与骨转移的发生呈正相关，uNTX敏感性高于血清AKP活性和Ca^2＋浓度，在鉴别骨转移瘤和监测病变进程中有预测价值，也是评价骨转移瘤患者疗效反应的早期客观指标之一。

Objective To analyze the significance of urinary typeⅠcollagen cross-linked N-telopeptides （uNTX） for the prognosis and response to therapy of bone metastatic neoplasms. Methods The subjects were divided into 3 groups： A, B and C. The levels of uNTX were measured by enzymatic immunoassay kit,and the activity of serum alkaline phosphatases（AKP） and calcium concentration were measured simuhanuously. Results uNTX levels positively correlated with bone metastatic neoplasms,and were markedly high in the patients with extensive bone collagen breakdown. Conclusions uNTX is more sensitive than the activity of serum AKP and plasma calcium concentration for bone metastasis of neoplasms, so it is significant in differentiating and monitoring bone metastatic neoplasms. The measurement of uNTX is an early objective methods for evaluation of prognostic response to therapy of bone metastatic neoplasms.