低剂量电离辐射对松果腺细胞凋亡的影响

Effect of low dose radiation on cell apoptosis of pineal gland

目的:通过低剂量辐射兴奋效应的动物模型,进一步探讨低剂量X射线全身照射对小鼠松果腺细胞凋亡的影响。方法:采用0.075Gy X射线全身照射后不同时间间隔取松果腺,采用流式细胞术(FCM)检测照射后不同时间松果腺细胞凋亡百分率的时程变化。结果:低剂量电离辐射全身照射12h、24h、48h后松果腺细胞凋亡百分率降低(P<0.01)。结论:低剂量辐射可抑制松果腺细胞的凋亡。

Objective： To observe the effect of low dose radiation on cell apoptosis of pineal gland in mice. Methods： The percentage of the cell apoptosis was analyzed by flow cytometry after staining of pineal gland with propidium iodine （PI） after whole body irradiation with 0.075Gy X-rays. Results： After whole body irradiation of low dose radiation, the percentage of the cell apoptosis of pineal gland decreased in 12h, 24h, 48h （P〈0.01）. Conclusion： Low dose radiation can inhibit the apoptosis of pineal gland cells.