骨科无菌手术预防应用抗菌药的成本-效果分析

Cost-effectiveness Analysis of Common Antibiotics for Prevention of Post-operation Infections in Orthopedic Aseptic Operations

目的:探讨骨科无菌手术应用5种常用抗菌药预防感染的经济效果。方法:随机抽取2006年1～3月的骨科无菌手术135例,Ⅰ类伤口,术前无感染指征,统计病例一般资料和抗菌药使用情况,对5种常用抗菌药预防骨科手术感染进行回顾性分析,比较5种常用抗菌药预防手术感染的成本-效果。结果:在调查的5种药物中,头孢呋辛钠是预防骨科无菌手术感染的最佳用药选择。结论:开展成本-效果分析有助于合理用药,控制用药成本。

Objective： To evaluate the economic effectiveness of five antibiotics for prevention of post-operation infections in orthopedic aseptic operations. Method： According to the application of five commonly-used antibiotics to 135 cases of orthopedic aseptic operations, which were analogous wounds and had no infectious signs before surgery, a cost-effectiveness analysis was comparatively made by using the principle of pharmacoeconomics for the five antibiotics for prevention of post-operation infections. Result： In the principles of the pharmacoeconomics, cefuroxime sodium was the best antibiotic to prevent the infection of orthopedic aseptic operations. Conclusion： The cost-effectiveness analysis is very helpful to choose the best rational therapeutic regime and to gain the maximal therapeutic effectiveness with a minimal cost.