摘要
RNA干扰(RNA interference,RNAi)技术能特异性降解mRNA,沉默靶基因,在转录后水平抑制基因的表达,从而可用来进行基因功能的分析和药物靶标的研究。RNAi技术日趋成熟,已被广泛应用于生命科学的各个领域。在神经科学上,尤其是在神经退行性疾病,如阿尔茨海默病、帕金森病、亨廷顿病、脊髓小脑性共济失调、肌萎缩性侧索硬化症、朊病毒病等的研究中取得了显著进展,RNAi的应用为神经退行性疾病发病机制的揭示和治疗另辟了蹊径。
RNA interference （RNAi） technique can specifically degradate mRNA, silence the target gene and suppress the expression of gene at post-transcription level, so it can be used to analyze the gene function and study the drug target. RNAi technique has been extensively applied to various fields of life science due to its great promotion. RNAi has got much appealing advancement in neuroscience, especially in Alzheimer＇s disease （ AD）, Parkinson＇s disease （ PD）, Huntington＇s disease （ HD）, spinocerebellar ataxia（SCA）, amyotrophic lateral sclerosis（ALS）, and prion disease. A novel path for revealing the pathogenesis and therapy of neurodegenerative diseases was offered by the application of RNAi technique in neuroscience.
出处
《国外医学（药学分册）》
2007年第2期81-86,共6页
Foreign Medical Sciences(Section of Pharmarcy)
基金
国家重点基础研究发展计划(973计划)资助项目(2004CB518907)
国家自然科学基金资助项目(No30200367
No30600760)
