期刊文献+

消风散对Ⅳ型超敏反应中IL-4、IFN-γ及sIL-2R的影响 被引量:13

Effects of Xiaofeng Powder on IL-4,IFN-γ and sIL-2R in Delayed Hypersensitivity
下载PDF
导出
摘要 目的研究消风散对2、4-二硝基氯苯(DNCB)诱导小鼠Ⅳ型超敏反应的影响。方法建立小鼠Ⅳ型变应性接触性皮炎(ACD)模型,观察消风散对小鼠耳肿胀、外周血白细胞数的影响,采用ELISA法检测小鼠血清中的白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)及可溶性白细胞介素-2受体(sIL-2R)的含量。结果消风散可改善DNCB引起的小鼠耳部肿胀,明显降低末梢血中白细胞总数,抑制IFN-γ及sIL-2R水平,提高IL-4含量。结论消风散能抑制Ⅳ型超敏反应,作用机制与抑制白细胞总数、调节细胞因子及受体有关。 Objective To study the effects of Xiaofeng Powder on IL-4, IFN- γ and sIL-2R in delayed hypersensitivity and to explore the mechanism of treatment. Methods The mice model of allergic contact dermatitis was formed by DNCB. The effect of Xiaofeng Powder on ear swelling and leukocyte counts of the model mice were observed. The serum levels of interleukin-4 (IL-4), interferongamma (IFN-γ) and soluble interleukin-2 receptor (sIL-2R) of the mice were detected by enzyme-linked immunosorbent assay (ELISA). Results Xiaofeng Powder could inhibit ear sweUings and obviously reduced the total amount of leucocytes. Xiaofeng Powder could heighten IL-4 level and reduce the level of IFN-y, sIL-2R. Conclusion Xiaofeng Powder has the function of inhibiting delayed hypersensitivity. The mechanism of treatment may be related to inhibiting the total amount of leucocytes, regulating cell factor and receptor.
机构地区 辽宁中医药大学
出处 《中国中医药信息杂志》 CAS CSCD 2007年第4期37-38,共2页 Chinese Journal of Information on Traditional Chinese Medicine
关键词 消风散 Ⅳ型超敏反应 白细胞介素-4 Γ-干扰素 可溶性白细胞介素-2受体 XiaofengPowder delayed hypersensitivity IL-4 IFN-γ sIL-2R
  • 相关文献

参考文献7

二级参考文献31

  • 1梁君山,魏伟,周爱武,陈敏珠,徐叔云.白细胞介素Ⅰ的检测及白芍总甙对其产生的影响[J].中国药理学通报,1989,5(6):354-357. 被引量:51
  • 2王兴鹏,袁耀宗,徐家裕.前列环素血栓素和氧自由基在大鼠急性胰腺炎并发肺损伤中作用及川芎嗪的影响[J].中国病理生理杂志,1994,10(1):64-67. 被引量:9
  • 3丁桂凤 席宏丽.用活化小鼠脾细胞测定IL-2[J].上海免疫学杂志,1988,8(1):64-70.
  • 4尚红生 邓玉兰 等.小鼠IL-1测定方法的探讨及中药香菇菌多糖对IL-1产生的作用[J].中国免疫学杂志,1986,2(2):70-70.
  • 5田中.实用临床微循环学[M].北京:军事科学出版社,1989.28.
  • 6章鸣玉.一种简易的大鼠足容积测量法[J].中国药理学通报,1986,2(2):57-58.
  • 7林志共.异谷树碱的抗炎作用[J].中国药理学通报,1987,3(4):224-228.
  • 8何凤慈 唐汝愚 姚丹帆 等.粉防己碱对炎症血管通透性和嗜中性自细胞功能的影响[J].中国药理学报,1989,10(3):249-249.
  • 9Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone I ,Definition according to profiles of lymphokine activities and secreted proteins. J Inmmnol, 1986, 136:2348.
  • 10Sad S, Mareottc R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8 T cells into cytotoxic CD8 + T ceils secreting Th1 or Th2 cytokincs. Immunity, 1995,2(3): 271.

共引文献87

同被引文献170

引证文献13

二级引证文献140

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部