创伤后应激障碍患者的脑干诱发电位分析

Study on brain-stem auditory evoked potentials in patients with post-traumatic stress disorder

目的：探讨创伤后应激障碍（PTSD）患者的脑干听觉诱发电位（BAEP）变异特点及其与心身症状的关系。方法：对54例PTSD患者进行BAEP检测和心身症状评定，分析BAEP与心身症状的相关性，并与健康人作比较。结果：PTSD患者Pz脑区Ⅲ、Ⅴ波绝对潜伏期和Ⅰ～Ⅲ波间期均延迟，Ⅲ～Ⅴ波间期缩短，Ⅴ／Ⅰ波波幅比下降；症状自评量表（SCL-90）的总分及其躯体化、强迫、抑郁、焦虑因子分，事件影响量表（IES）的总分及其回避、闯入因子分显著高于对照组；Pz脑区BAEP各波的观察指标与大部分心身症状的相关有显著性意义。结论：BAEP检测为PTSD患者的临床辅助诊断提供了一种敏感、客观的电生理学手段。

Objective： To investigate the features of brain-stem auditory evoked potentials （BAEP） in the patients with post-traumatic stress disorder （PTSD） and the relationship between the BAEP and psychosomatic symptoms. Method： Fifty-four patients with PTSD were detected with BAEP and evaluated with psychosomatic symptoms. The relationships between BAEP and psychosomatic symptoms were analyzed and compared with the healthy controls. Results：Compared with the control group, PTSD group showed more prolonged wave Ⅲ, Ⅴ latency and wave Ⅰ -Ⅲ inter-peak latency, shorter wave Ⅲ- Ⅴinter-peak latency, and amplitude ratio of wave Ⅴ / Ⅰ , and higher scores of symptom checklist 90 （SCL-90） and impact of event scale（IES）. Mostly items of BAEP were significantly related to psychosomatic symptoms. Conclusion： BAEP test provides a sensitive and objective electrophysiological means in diagnosis for patients with post-traumatic stress disorder.