摘要
目的:探讨文拉法辛缓释剂的疗效与不良反应。方法:将72例服用文拉法辛缓释剂患者(缓释剂组)与68例服用文拉法辛速释剂患者(速释剂组),从疗效和不良反应等方面进行对照研究。结果:缓释剂组起效时间较快,不良反应较少。速释剂组转躁者较多,排尿困难、癫癎、呕吐仅出现在速释剂组,但撤药反应仅发生于缓释剂组。两组治疗6周后无效的患者进行交叉用药,50.0%及53.3%的患者取得疗效。结论:文拉法辛缓释剂起效较快,不良反应较小,更适合用于临床。
Objeelive：To detect the efficacy and side effect of release venlafaxine. Method： The efficiency and side effect of extended released （72 cases,XR） and immediate release venlafaxine （68 cases, IR） were compared. Results：Extended release venlafaxine had faster in onset of effciency. Changed manic was more in group IR than that in group XR.Dysuria, epilepsy and vomit happened only in group IR, while drug-removing reaction occurred only in group XR, For patients without improvement after 6 weeks original treatment in XR group and IR group, they were shifted to the other group, Afterwards, 50.0% and 53,3 % of them experienced favorable results, Conclusion： Extended release venlafaxine has faster efficiency,milder side effects, It is more available in clinical use.
出处
《临床精神医学杂志》
2007年第1期34-35,共2页
Journal of Clinical Psychiatry
关键词
文拉法辛
缓释剂
速释剂
venlafaxine
extended release
immediate release
