破骨细胞分化、形成过程中表现型特点

Characteristics of osteoclast in process of differentiation and formation

综述认为,体外培养破骨细胞是研究骨吸收机理和筛选治疗骨质疏松症药物的基础,建立破骨细胞的分离培养体系,有助于揭示骨吸收机理,了解破骨细胞的生物特性,为破骨细胞学及相关疾病的发病机制研究和防治提供理论依据。因此,了解体外培养的破骨细胞在分化、形成过程中的一些特异性分化抗原或蛋白显得尤其重要。

Osteoclast cultured in vitro was the foundation of researching the mechanism of bone resorption and sieving the medicine for curing osteoporosis. The establishment of isolated culture system of osteoclast was facilitated to reveal the mechanism of bone resorption and understand the biologic characters of osteoclast. Besides,it provided theoretical evidences for studying osteoclast, researching the pathogenesis of related disease, preventing and curing this kind of disease. Therefore, it was important to study specificity differentiation antigen or protein in the process of differentiation and formation of osteoclast in vitro culture.