卒中散对脑出血大鼠抓握能力的改善及血清S100B水平的影响

Improvement of Hold-abilities of Zuzhong Powder on the Intracerebral Hemorrhage Pats and its Effect on the Serum levels of S100B Protien

目的:探讨卒中散对脑出血大鼠抓握能力的改善及血清S100B水平的影响,为其临床应用提供理论依据。方法:40只SD大鼠随机分成假手术组、手术组、卒中散组、脑复康组,参照Rosenberg法制作大鼠脑出血模型,造模第2天测定大鼠抓握能力,用ELISA法检测造模后24h及48h血清S100B水平。结果:(1)卒中散组大鼠抓握能力明显好于手术组,两者比较有显著差异(P<0.05)。(2)卒中散组大鼠血清S100B水平明显低于手术组,两者比较有显著差异(P<0.05)。结论:卒中散能明显改善脑出血大鼠抓握能力,降低血清S100B水平,具有神经保护作用。

Objective： to investigate the Improvement of Hold-abilities of Zuzhong-powder on the intracerebral hemorrhage （ICH） rats and its effect on the serum levels of S100B protien.to provide theory.basis for its clinical application. Methods： 40 SD rats were randomly divided into sham-operation group,operation group,Zuzhong-powder group,Piracetam group,The ICH model of rats were made by Rosenberg method, S100B protien was detected by ELISA method at24h,48h, to examine the Hold-abilities of rats at the second day. Results： （1） Zuzhong-powder could significantly improve the Hold-abilities of ICH rats ,comparing to the operation group （P 〈0.05）. （2） The serum levels of S 100B protein of Zuzhong-powder was significantly lower compared to the operation group （P 〈0.05）.Conclusion： Zuzhong-powder can significantly improve the Hold-abilities of ICH rats,to decrease the serum levels of S100B protein,and protect the intracerebral nerves.