摘要
促血管生成素(angiopoietin,Ang)是一个与血管新生密切相关的家族。对肿瘤形成过程中的血管生成、稳定、转移、退化起重要作用。阐明促血管生成素在肿瘤中的作用,对肿瘤治疗有重要意义。促血管生成素与内皮细胞特异性酪氨酸酶受体Tie-2结合发挥作用,是近年发现的唯一一个含有受体激动剂和受体抑制剂的血管生长因子家族。本文将就血管生成素在生理发育和肿瘤血管新生中的作用等方面的研究进展进行综述。
Angiopoietin is deeply involved in tumor angiogenesis. Tumor vascularization plays a critical role in the process of vascular development, steadiness, migration and degeneration. As to treating carcinoma, it is important to clarify the effect of angiopoietin on tumor in human body. The extracellular domain of the receptor tyrosine kinase Tie - 2 has been combined with angiopoietin to function, which is found to be the only vascular growth factor family with receptor activator and receptor suppressor in recent years. This paper reviews the research development of the effect of angiopoietin on body development and tumor angiogenesis.
出处
《内蒙古医学院学报》
2007年第1期70-72,共3页
Acta Academiae Medicinae Neimongol
