摘要
有关β2-肾上腺素能受体（β2-AR）基因与哮喘的相关研究大多数都集中于两个常见的编码区非同义突变，即Arg16Gly和Gln27Glu，研究的结果存在着大量的不一致性。近来对β2-AR单倍型的研究表明，β2-AR基因的多个SNP以及它们的相互作用即单倍型在哮喘发病中比这两个常见的多态性更为重要。最近三个meta-分析表明Arg16Gly以及Gln27Glu多态性与哮喘发病无关，尽管已有研究证明它们与哮喘的其它表型相关。β2-AR基因不是哮喘发生的主要危险因素，但其多态性在决定药物反应性方面很可能重要的。本文综述了近年来有关β2-AR基因多态性在哮喘研究中的作用和这些研究的局限性以及将来β2-AR基因多态性的研究方向。
Candiate gene association studies of β2-adrenergic receptor（β2-AR） and asthma have been dominated by analysis of the two common non-synonymous coding single nucleotide polymorphisms, Arg16Gly and Glu27Gln. Published studies have yielded inconsistent results. Recent reports of haplotype effects of the β2-AR suggest that SNPs other than two common coding polymorphisms and their interactions are important in asthma. Three recent meta-analyses on the effects of these two polymorphisms have found no associations with asthma, although there were suggestions of associations with other asthma related phenotypes. Polymorphisms of β2-AR are not major risk factors for the development of asthma. These polymorphisms are likely to be important,however,in determining drug response. This review examined the recent evidence for the significance of β2-AR polymorphisms in asthma, the limitations of this evidence, and future directions in the study of these polymorphism.
出处
《国际呼吸杂志》
2007年第7期489-494,共6页
International Journal of Respiration
