喉癌花生凝集素受体的研究

A studyon the peanut lectin receptors in patient of laryngeal carcinoma

应用ＡＢＣ免疫组化技术观察了１７例喉癌、癌旁及正常喉粘膜上皮内花生凝集素（ＰＮＡ）受体分布，结果表明癌细胞内ＰＮＡ呈强阳性表达，毗邻正常喉粘膜上皮细胞未见强阳性表达；在不同的喉癌组织学分级之间，ＰＮＡ的表达呈不同程度，其差异具有显著性（Ｐ＜０．００５）。提示ＰＮＡ受体可能是喉癌的一种重要标志，其分布与喉癌的分化、增殖有关，为喉癌形态学早期诊断和鉴别诊断提供了一种辅助手段。

Abstract The distrihution of peanut lectin(PN A ) receptors in l7 patients of laryngeal carcino-mas epithelial cells adjacent to cancer and normal laryngeal epithelial cells were studied by a ABC immunohistochemistry servey, The results showed that PNA were strong positive in the cancer cells and there were no positive expression in nearly normal epithelial cells. The expression of PNA were significantly different between the different histopathological grade of carcinomas(P<0. 005).The present study suggested that PNA receptor may be an im-portant marker of laryngeal carcinoma. And its distribution may be related with the cancer.The demonstration of PNA receptor could be used as an accessory wfly for the early and dif-ferential diagnoses of laryngeal carcinoma.