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Survivin在非霍奇金淋巴瘤中的表达及意义 被引量：2

Significance and expression of Survivin protein in non-Hodgkin′s lymphoma
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摘要 目的:探讨Survivin抗原在非霍奇金淋巴瘤(NHL)中的表达及临床意义。方法:采用免疫组织化学SP方法,检测Survivin在52例NHL及12例淋巴结反应性增生(RH)中的表达情况。结果:Survivin在淋巴结反应性增生中的阳性表达率明显低于NHL,侵袭性NHL表达水平明显高于惰性NHL。Survivin在非霍奇金淋巴瘤的表达与性别、年龄、患者临床分期、有无全身症状、患者淋巴瘤细胞来源、首发部位无关。LDH<250 U/L NHL Survivin阳性表达率明显低于LDH>250 U/L NHL Survivin阳性表达率。Survivin阳性表达率>25%非霍奇金淋巴瘤患者与阳性表达率<25%非霍奇金淋巴瘤患者相比较,平均生存期短。结论:Survivin与NHL的发生发展有关,并可对预后判断提供参考依据。 Objective： To explore the expression of Survivin in non-Hodgkin＇s lymphoma cells with variable aggressiveness and its clinical significance. Methods： The SP immunohistochemistry staining method was used to detect the expression of Survivin. Results： The positive rate of Survivin in the reactive hyperplasia of the lymph node was lower than that in non-Hodgkin＇s lymphoma. The positive rate of Survivin was related to the aggressiveness of non-Hodgkin＇s lymphoma, but it was not related to the sex, age, clinical stage, body symptoms, immunotype and initial organ. Different Survivin expressions were found between different levels of LDH. High Survivin expression was associated with low survival stage. Conclusion： Survivin may play certain roles in the oncogenesis and the progression of non-Hodgkin＇s lymphoma, and it has positive effects on the prognosis of non-Hodgkin＇s lymphoma.
作者 刘新 李颖 徐功立 许洪志
机构地区 山东大学医学院山东省立医院血液科
出处 《山东大学学报（医学版）》 CAS 北大核心 2007年第3期283-285,289,共4页 Journal of Shandong University:Health Sciences
关键词 免疫组织化学 淋巴瘤 非霍奇金 SURVIVIN Immunohistochemistry Lymphoma, non-Hodgkin Survivin
分类号 R733.4 [医药卫生—肿瘤]
  • 相关文献

参考文献12

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共引文献21

同被引文献28

  • 1黄慧强,彭玉龙,黄欣,潘战和,侯景辉,吴秋良.Survivin在T细胞非霍奇金淋巴瘤组织中的表达及临床意义[J].中山大学学报（医学科学版）,2006,27(2):221-224. 被引量：7
  • 2张俊萍,王毓銮.恶性淋巴瘤的生物治疗进展[J].白血病．淋巴瘤,2006,15(6):474-476. 被引量：7
  • 3史周印,张明智,李道明,高冬玲,庞霞.非霍奇金淋巴瘤组织中Survivin的表达及细胞凋亡检测[J].郑州大学学报（医学版）,2007,42(1):151-154. 被引量：2
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引证文献2

二级引证文献4

山东大学学报（医学版）
2007年 第3期

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