VEGF、uPA在侵袭性垂体腺瘤中的表达及意义

Expression and clinical significance of VEGF and uPA in human invasive pituitary adenomas

目的探讨血管内皮生长因子(VEGF)、尿激酶型血纤溶酶原激活剂(uPA)在侵袭性垂体腺瘤和非侵袭性垂体腺瘤中的表达及其临床意义。方法应用免疫组化法检测26例侵袭性垂体腺瘤和20例非侵袭性垂体腺瘤中VEGF、uPA的表达,并结合临床资料分析。结果VEGF和uPA在侵袭性垂体腺瘤的表达明显高于在非侵袭性垂体腺瘤中的表达,VEGF和uPA的表达水平与垂体腺瘤的侵袭性正相关。其中uPA在垂体腺瘤中的表达强度高于VEGF。结论VEGF和uPA与垂体腺瘤侵袭性生长及复发相关。

Objective The vascular endothelial growth factor （VEGF） and urokinase-type plasminogen activator （uPA） are important factors for tumor angiogenesis. In the present study, the expression of VEGF and uPA in pituitary adenomas were examined, and the clinical significances were also evaluated. Methods The expression of VEGF and uPA were examined using immunohistochemical method in 26 cases of invasive pituitary adenomas and 20 cases noninvasive pituitary adenomas. The clinical information was also reviewed and analyzed. Results Overexpression of VEGF and uPA were detected in invasive pituitary adenomas while lower expression presented in noninvasive pituitary adenomas. The expression levels of VEGF and uPA considerably correlated with development of the invasive pituitary adenomas. The expression level of uPA in the pituitary adenomas was higher than that of VEGF. Conclusion The expression of VEGF and uPA may have positive correlation with invasion and recurrence of pituitary adenomas, and may have indicative value to their prognosis.