异搏定区域动脉灌注在阻止急性胰腺炎重症化治疗中的作用

Therapeutic Effects of Continous Regional Arterial Infusion with Verapamil on Progression of Acute Pancreatitis

目的探讨钙拮抗剂异搏定区域动脉灌注在阻止急性胰腺炎重症化治疗中的作用。方法45例轻型急性胰腺炎患者被随机分为3组：常规治疗组、静脉治疗组及动脉灌注组。入院后，常规治疗组采取常规保守治疗；静脉治疗组行合理液体治疗，静脉注射异搏定；动脉灌注组液体补充同时采用持续动脉灌注异搏定1～2周。测定治疗后1、4及7d血清肿瘤坏死因子-α（TNF-α）、白介素-18（IL-1β）、黏附分子-1（ICAM-1）及P-选择素（P-selectin）水平。结果治疗后4、7d，血清TNF-α和P-selectin水平动脉灌注组较静脉治疗组及常规治疗组明显降低（P〈0．05）；血清IL-1β水平动脉灌注组和静脉治疗组均较常规治疗组明显降低（P〈0．05）；血清ICAM-1水平动脉灌注组明显低于常规治疗组（P〈0．05）。结论持续区域动脉灌注异搏定可能通过减少细胞因子的产生，抑制黏附分子P-selectin和ICAM-1的上调，阻止急性胰腺炎重症化发展。

Objective To investigate therapeutic effects of continous regional arterial infusion with verapamil on preventing the progression of acute pancreatitis. Methods Forty-five patients with mild acute pancreatitis were randomly divided into three groups： conventional treatment group, intravenous treatment group and arterial infusion group. After admission, conventional treatments were performed in conventional treatment group. Reasonable fluid and verapamil were intravenously injected to the patients in intravenous treatment group, and fluid treatments and continous regional arterial infusion with verapamil were performed in arterial infusion group for 1- 2 weeks. The levels of serum TNF-α, IL-1β, ICAM-1 and P-selectin were determined on the 1st, 4th and 7th day after treatment, respectively. Results On the 4th and 7th day after treatment, the levels of serum TNF-α and P-selectin significantly decreased in arterial infusion group compared with the other two groups （P〈0.05）, while the level of serum IL-1β significantly decreased in arterial infusion group and intravenous treatment group compared with the conventional treatment group （P〈0.05）. The level of serum ICAM-1 significantly decreased in arterial infusion group compared with the conventional treatment group （P〈0.05）. Conclusion Continous regional arterial infusion with verapamil could reduce the production of inflammatory cytokines and inhibit the up-regulation of adhesion molecules ICAM-1 and P-selectin, and prevent the progression of acute pancreatitis ultimately.