肠易激综合征患者生活质量、胃肠道症状及精神心理状况分析

Quality of life,gastrointestinal symptoms and mental-psychological function in patients with irritable bowel syndrome

目的调查肠易激综合征(IBS)患者的生活质量、胃肠道症状及精神心理状况,分析影响其生活质量的主要因素。方法应用IBS特异生活质量调查表、HAD焦虑抑郁量表和胃肠道症状调查表对IBS患者(n=55)及健康人(对照组,n=40)进行问卷调查,了解其生活质量、胃肠道症状及精神心理状况,并对结果进行统计分析。结果IBS患者生活质量各方面积分均低于对照组(P<0.05)。相关分析显示,生活质量积分与症状严重程度无关,而与焦虑、抑郁积分呈负相关(P<0.05)。结论IBS患者生活质量明显降低,不良精神心理状况是其主要影响因素。

Objective To investigate the quality of life （QOL）, gastrointestinal symptoms and mental status of patients with irritable bowel syndrome （IBS）, and to find out the possible factors affecting the patients＇ QOL. Methods The questionnaires which included three forms were sent to 55 IBS patients and 40 healthy controls recruited from the authors＇ clinical department. IBS was diagnosed according to the Rome II criteria, and patients with organic diseases were excluded from this study. The nine-item scores of QOL in all cases were calculated by using the disease-specific form included in the questionnaire of QOL. The mental-psychological status in all cases was evaluated by using the Hospital Anxiety and Depression Scale （HAD）. The gastrointestinal symptoms in IBS patients were recorded and graded according to the Gastrointestinal Symptom Rating Swale （GSRS）. The data mentioned above were analyzed with regression model. Results Patients with IBS had statistically significant lower scores （P〈0. 05） for nine IBSQOL domains compared with that of the normal control. On the other hand, IBS patients had significantly higher anxiety and depression score than those of healthy controls （P〈0. 05）. A positive correlation was observed between the QOL of IBS patients and mental-psychological status in regression model （P〈0. 05）. Conclusions IBS has a significant impact on IBSQOL of patients, which is related to the abnormal mental-psychological status.