自体富血小板凝胶在难治性糖尿病皮肤溃疡中的应用

APPLICATION OF AUTOLOGOUS PLATELET-RICH GEL TO REFRACTORY CHRONIC DIABETIC CUTANEOUS ULCERS

目的对自体富血小板凝胶(autologous platelet-richgel,APG)在难治性糖尿病皮肤溃疡中的应用进行综述。方法广泛查阅文献,对APG促进糖尿病皮肤溃疡愈合的作用机制和疗效进行综合分析。结果APG具有促进溃疡愈合的作用,特别是在难治性糖尿病皮肤溃疡方面有较好的效果。其主要作用机制可能与APG中含有高浓度的各种生长因子有关。结论APG具有促进难治性糖尿病皮肤溃疡愈合的作用,有良好的应用前景,可以作为一种新的辅助治疗手段应用于临床。

Objective To review and evaluate the clinical application of autologous platelet-rich gel （APG） in refractory chronic diabetic cutaneous ulcers. Methods The latest literature was extensively reviewed, and the potential mechanism of APG for healing diabetic cutaneous ulcers was discussed. Results APG accelerated the ulcer healing, especially in healing the refractory diabetic cutaneous ulcers, and the high-level growth factors from the platelet releasate were thought to be the major potential mechanism of the APG action. Conclusion APG can promote the healing of refractory chronic diabetic cutaneous ulcers. Topical haemotherapy with APG may be considered an adjuvant treatment of a multidisciplinary process and may be useful to the effective therapy of cutaneous ulcers.