男性青少年暴力攻击行为脑诱发电位研究

A neurophysiologic study of aggressive and violent behaviors in male delinquents

目的探索男性青少年暴力攻击行为的部分神经电生理学基础。方法以47例有官方暴力型违法乱纪记录的青少年（16-20岁）为研究组，无暴力攻击行为的职业高中学生41例为对照组，进行脑干听觉诱发电位、体感诱发电位和P300测验，比较两组间的差异。结果与对照组相比，有暴力攻击行为组脑干听觉诱发电位V潜伏期显著延长（P〈0．01），波Ⅲ波幅显著降低（P〈0．01），提示外周听觉刺激被过度过滤；P300的靶P3波潜伏期显著延长（P〈0．05），提示认知信息加工过程速度减慢；体感诱发电位N1波潜伏期显著缩短（P〈0．05），P2波波幅显著增高（P〈0．01），提示体感刺激皮层反应增强。结论有暴力攻击行为的青少年脑诱发电位异常，提示大脑皮层唤醒水平低下，认知功能损害，存在对体感刺激的感觉搜寻增强。

Objective To explore the neurophysiologic bases contributing to the aggressive and violent behaviors in male delinquents. Methods 47 male delinquents with official records of aggressive and violent violation and 41 normal controls were determined by brainstem auditory evoked potentials （BAER）, somatosensory evoked potentials （SEP） and auditory P300. Results Compared with the normals, the male delinquents with aggressive and violent behavior displayed prolonged V latency in BAER（ P 〈 0. 01 ） reflecting more filtering out of peripheral auditory stimuli, prolonged P3 latency of target stimuli in auditory P300 during a standard oddball task（ P 〈 0. 05 ） indicating less efficient cognitive functioning. Also the violent and aggressive adolescents demonstrated shorter N1 latency （P 〈 0. 05 ） and increased P2 （ P 〈 0. 01 ）amplitude in SEP which implicated a significantly enhanced cortical response to somatosensory stimuli.Conclusions The abnormalities of BAER, SEP and P300 indicate decreased cortex arousal and secondary increasing sensation-seeking performance to somatosensory stimulus, which might partly underlies the neurophysiologic genesis of aggressive and violent behavior in male delinquents.