河北省精神分裂症的患病率、人口学特征及功能状况分析

Prevalence,demographic characteristics and function status of the schizophrenia in Hebei province

目的了解精神分裂症的患病率、人口学特征及社会生活功能状况。方法采用随机抽样方法，调查河北省18岁以上人群24000人，调查筛选工具采用改编后的一般健康问卷12项（GHQ-12），以《DSM—Ⅳ—TR轴Ⅰ障碍定式临床检查》病人版（SCID—I／P）为调查的诊断工具。功能状况评价采用功能大体评定量表（GAF）。结果精神分裂症时点患病率为0．546％（95％CI：0．445％～0．646％），终生患病率为0．662％（95％CI：0．551％～0．772％）。时点患病率：城市0．440％，农村0．561％，农村虽高于城市，但无显著性差异（u=0．80，P〉0．05）；女性0．649％，男性0．443％，女性明显高于男性（u=2．01，P〈0．01）；30～60岁患病率较高。偏执型占63．8％。Logistic回归分析显示，影响精神分裂症的危险因素有分居／离婚（OR=9．58）、独身（OR=6．99）、家庭年收入0～5000元（OR=4．2），保护性因素有已婚（OR=0．38）、无宗教（OR=0．46）；严重程度以中度和重度多见，社会和生活功能受损明显，GAF评分平均为（48．41±19．07）分。结论精神分裂症是一种患病率相对较高的重性精神疾病，严重影响患者的社会生活功能。

Objective To understand the prevalence, demographic characteristics and function status of the schizophrenia in Hebei province. Methods Sum total of 24,000 randomly selected samples atof ages over 18 and above representing the whole population in the province were investigatedselected among the crowd and data were collected. The tools of the rRevised version of edition of the General Health Questionnaire （GHQ-12） was used for screening and for the investigation, Structured Clinical Interview for DSM-Ⅳ-TR Axis Ⅰ Disorders-Patient Edition （SCID-I/P） was used for diagnosiess. and GAF for analysis of thewas used to assess the function status were adapted throughout the survey. Results Current prevalence of the schizophrenia was 0. 546% （95%CI： 0. 445% -0. 646% ）, lifetime prevalence was 0. 662% （95%CI： 0. 551% -0. 772% ）. There was no significant difference on the point prevalence between rural areas （0. 561% ） in rural population and urban areas （0. 440% ） in townsmen （u = 0. 80, P 〉 0. 05 ）. While the currentpoint prevalence of 0. 649% in female was higher than that of 0. 443 % in male （u = 2. 01, P 〈 0.01 ）. People rangedThe age group of （30 -60） years old showedhad higher prevalence of the schizophrenia than other ages groups. Paranoid schizophrenia accounted for 63.8% of the totalin total schizophrenia patients. Logistic regression analysis showed that the risk factors of being schizophreniato the disease were the separation/divorcement（ OR = 9.58 ）, bachelorhood （OR = 6.99） , and family annual average annual income below 5,000 RMB （OR =4. 2）. On the other hand, the protective factors fromto avoid the disease were the marriageed （ OR =0. 38） and no religion （ OR =0.46）. The sSevere to middlemoderate severity were common. Social and personal lifeliving functions of patients with the schizophrenia were affectedimpaired seriously. Average GAF score was （48.41 ± 19. 07）. Conclusions Schizophrenia was not a rare a kind of common mental diseasemental disorder with highera moderate level of prevalence and affecting the social and personal lifeliving functions were greatly impairedseriously.