缓激常泰拮抗细菌潜生体对肥大细胞激活作用的实验研究

Effect of GlcNAc against activation of bacterial cryptic growth cells to mast cells

目的观测缓激常泰拮抗细菌潜生体激活肥大细胞的作用。方法以头孢呋辛钠诱导大肠杆菌产生,体外以细菌潜生体为对照,分别观测不同剂量缓激常泰对细菌潜生体激活肥大细胞的拮抗作用。结果中、高剂量的缓激常泰具有显著的拮抗作用,与对照组有显著性差异。结论一定剂量的缓激常泰具有稳定肥大细胞的作用。

Objective To demonstrate the inhibitory effect of GIcNAc on the bacterial cryptic growth cells （CGC） activating mast cells. Methods E. coli. CGC was induced by Zinacef, in vitro taking the CGC acting on mast cells as control. The antagonistic effect of GlcNAc on mast cells activated by CGC with different dosages was demonstrated. Results The significant inhibitory effect of GlcNAc against the activation of CGC on mast cells was found as compared with controls. Conclusion Certain dosage of GlcNAc possesses the capacity of stabilizing mast cells. This has laid a foundation for elucidating the therapeutic effect of GlcNAc on irritable bowel syndrome.