孕母血型抗体与新生儿ABO溶血病的关系研究

Relationship between ABO hemolytic disease of newborn and maternal antibody

目的研究O型孕母血型抗体效价与新生儿ABO溶血病之间的关系。方法通过对122例产前检测O型母亲的血型抗体效价,新生儿出生时做血型血清学检查,胆红素和血红蛋白的检测,综合评价产前检查孕母血型抗体与新生儿ABO溶血病的关系。结果孕母的血型抗体滴度与新生儿溶血病有显著相关性(r=0.385)。血型抗体滴度愈高发生溶血病的机会愈大(P<0.01),同时血型抗体滴度与新生儿血红蛋白下降有关(r=0.563,P<0.01),并且滴度愈高新生儿24h内胆红素浓度升高愈明显(P<0.01)。结论孕母血型抗体的检测对新生儿溶血病有明确监测作用,对新生儿溶血病的发生、发展有良好的预见性。

Objective To study the relationship between ABO hemolytic disease of newborn and maternal antibody. Methods The titer of blood group antibody in 122 mothers of O blood group during prenatal diagnosis and blood group serology, bilirubin and hemoglobin level of newborn infants were tested with routine methods. The relationship between ABO hemolytic disease of newborn and the titer of blood group antibody was studied, Results The titer of blood group antibody was remarkably related with ABO hemolytic disease of newborn （P 〈0.01 ）,with the descent of hemoglobin （P 〈0, 01 ） and with bilirubin level of newborn within 24 h （P 〈 0, 01 ）, Conclusion Detecting the titer of maternal blood group antibody can monitor and predict ABO hemolytic disease of newborn infants.