摘要
目的评价奥硝唑和培氟沙星体外联合应用对牙周病原菌抗菌效果。方法检测两药配伍的可行性。根据2种含药纸片抑菌环交界角形状,初步判断2种药物联合后对受试菌的作用效果。根据琼脂棋盘稀释法定量判断不同浓度组合药物联用后对受试菌的最低抑菌浓度并计算分级抑制浓度FIC指数。结果2种药物溶液混合后无明显理化特性改变。牙龈卟啉单胞菌、具核梭杆菌、中间普氏菌、消化链球菌、金黄色葡萄球菌、表皮葡萄球菌6株标准菌株的FIC指数分别为0.3125、0.375、0.5625、0.75、1.0625、1.0625。结论2种药物无配伍禁忌,对厌氧菌抗菌活性呈相加作用,对非厌氧菌仅培氟沙星起作用。
Objective To investigate the feasibility of combined ornidazole and pefloxacin for peridontal pathogen in vitro and estimate their antibacterial activities. Methods By the shape of comiform of two inhibition rings, the effect of two drugs was estimated. By the checkerboard method, the fractional inhibitory concentration （FIC） of two drugs was estimated when they were mixed at different concentrations. Results No obvious physical and chemical changes were observed when the two drugs mixed together. The FIC index of Pg, Fusobacterium nucleatum, Pi, Peptostreptococcus and Staphylococcus aureus was 0. 312 5, 0. 375, 0. 562 5, 0.75, 1. 062 5 and 1. 062 5 respectively. Conclusion The two drugs are of good compatibility and of addition effect on anaerobic bacterium, but only pefloxacin is effective on aerobic bacteria.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2007年第7期638-640,共3页
Journal of Third Military Medical University
关键词
奥硝唑
培氟沙星
抗菌活性
棋盘稀释法
ornidazole
pefloxacin
antibacterial activity
checkerboard method
