急性脑梗死患者颈动脉斑块与血清高敏感性C反应蛋白和IL-6的关系

Correlation of carotid plaque,serum high-sensitivity C-reactive protein and interleukin-6 levels in patients with acute cerebral infarction

目的探讨急性脑梗死患者颈动脉斑块与血清高敏感性C反应蛋白(hs-CRP)及白细胞介素6(IL-6)的关系。方法选择急性脑梗死患者180例,应用彩色多普勒超声检查颈动脉内膜-中膜厚度(IMT),并检测血清hs-CRP和IL-6水平。根据颈动脉超声检查结果分为斑块组78例(IMT≥1.2mm)与非斑块组(IMT<1.2mm)102例。结果斑块组患者的年龄[(62±9)岁]显著高于非斑块组[(51±10)岁,P<0.01)],伴有高血压(69%)及糖尿病(35%)的比例亦明显高于非斑块组(52%,18%,均P<0.05)。两组血脂水平比较差异无统计学意义(P>0.05)。hs-CRP水平增高的比例,斑块组(67%)显著高于非斑块组(47%,P<0.05),hs-CRP水平斑块组[(27.8±6.4)mg/L]亦显著高于非斑块组[(20.7±5.8)mg/L,P<0.01],而不稳定性斑块组hs-CRP水平[(37.5±7.2)mg/L]显著高于稳定性斑块组[(24.9±6.3)mg/L,P<0.01]。IL-6水平斑块组[(0.22±0.06)μg/L显著高于非斑块组[(0.20±0.08)μg/L,P<0.05]。结论急性脑梗死患者血hs-CRP和IL-6水平增高与颈动脉粥样硬化斑块的存在及其性质显著相关。

Objective To investigate the correlation of carotid plaque, serum high-sensitivity C-reactive protein （hs-CRP） and interleukin-6 （IL-6） levels in patients with acute cerebral infarction. Methods Carotid intima-media thickness （IMT） was measured by color Doppler uhrasonography in 180 patients with acute cerebral infarction, and their serum hs-CRP and IL-6 levels were measured. They were divided into plaque group （IMT≥1. 2 mm） and non-plaque group （IMT≥1. 2mm） according to the results of carotid uhrasonography. Results The mean age （ 62 ± 9 ） of patients in the plaque group was significantly older than that of the non-plaque group （51 ± 10, P 〈0. 01 ）. The proportion of accompanying hypertension （69%） and diabetes mellitus （35%） in the plaque group was also significantly higher than that in the non-plaque group （52% , P 〈 0. 05 ; 18% , P 〈 0. 05 ）. There was no significant difference in serum lipid levels between the two groups （P 〉 0. 05 ）. The increased proportion of serum hs-CRP levels in the plaque group （67%） was significantly higher than that in the non-plaque group （47%, P 〈0. 05）. Serum hs-CRP levels in the plaque group （27.8 ±6.4 μg/L） were also significantly higher than those of the non-plaque group （20. 7 ±5.8 mg/L, P 〈0. 01 ）, while the hs-CRP levels in unstable plaque group （37. 5 ± 7. 2 mg/L） were significantly higher than those in stable plaque group （24. 9 ±6. 3 mg/L, P 〈0. 01 ）. The serum IL-6 levels in the plaque group （0. 22 ±0. 06μg/L） were significantly higher than those in the nonplaque group （0. 20 ± 0. 08 μg/L, P 〈 0. 05）. Conclusion The elevated serum hs-CRP and IL-6 levels in patients with cerebral infarction was significantly correlated with the presenee and its characteristics of carotid atherosclerotic plaque.