摘要
本组用免疫组化SP法观察119例鼻咽癌(NPC)中P_(53)蛋白表达,半定量研究发现:①P_(53)表达阳性率为55.5%(66/119),表达的阳性细胞强度和阳性细胞数量与NPC的恶性度、组织学类型及淋巴结转移相关(P<0.005),尤其在未分化癌中有超表达现象。②在正常柱状、鳞状上皮,粘膜慢性炎症伴有单纯性增生者均阴性。而在不典型增生的鳞状上皮中有数量不等的轻或中度阳性表达,提示其基因突变趋向。③P_(53)表达阴性和阳性者平均生存期为64.5和31.1个月,两组间有显著性差异(P<0.05)。结果提示,检测NPC中P_(53)蛋白表达,可作为了解其生物学特性及预测预后的指标之一。
Abstract P53 expression in 119 cases of nasopharyngeal carcioma(NPC)and19 cases of nasopha- ryngeal mucosa obtained from non-cancer patients were studied by SP immunohistOchemical methods,The results showed that:1).P53positive rate was 55.5%(66/119)in NPC,the cellular staining intensity of P53 expression was related to malignant level,histologicaI typing and metastatic lymph node(P<0. 005).Undifferentiated carcinoma had over-expression of P53 protein. 2).P53 expression was negative in normal columnar epithelia,squamous epithelia,arid chronic nasopharyngitis-epithelia with hyperplasia,but P53 expression was positive in atypical dysplasia,3).The survival duration was 64.5 and 31.1 months in P53 expression(-)and(+) patients,respectively(P<0.005).We belleve that examination of P53 protein was helpful to understand the biological behavior and estimate the prognosis.
出处
《耳鼻咽喉(头颈外科)》
1996年第4期231-234,共4页
Chinese Arch Otolaryngology-Head Neck Surg