黄体功能不全不育妇女的卵泡发育研究

Study of Follicular Development in Infertile Women with Luteal Phase Dificiency

以子宫内膜组织学定期为诊断标准，对１７例黄体功能不全（ＬＰＤ）不育妇女及１０例正常对照者进行卵泡发育动态Ｂ超监测及激素水平动态测定。结果发现ＬＰＤ不育妇女的排卵前卵泡最大直径、小卵泡及未破裂卵泡黄素化（ＬＵＦ）发生率等均与正常对照组差异无显著性，围排卵期的总黄体生成素（ＬＨ）水平为（９４１．７±１２０．３）ｍＩＵ／ｍｌ，显著低于对照组（１５８３．４±４２．５）ｍＩＵ／ｍｌ，Ｐ＜０．０５。而雌激素（Ｅ２）及卵泡刺激素（ＦＳＨ）水平均与对照组相近。卵泡生长规律及Ｅ２、ＦＳＨ及ＬＨ等峰值出现的时间均与对照组相似。可以认为ＬＰＤ不育妇女具有ＬＨ分泌不足的特征。

outpatients who consulted for infertility were selected to undergo the systemic examinations such as serial ultrasonography monitoring and serum fertility hormones measurements. According to the criteria of Noyes′, 17 women were diagnosed as LPD, 10 women were diagnosed as controls. The preovulatory maximum diameter and the in-cidence of small follicles and LUF in LPD group were similar to that in controls. The serum integraded levels (-3d～2d) of LH in LPD group were significantly lower than that in controls (941.7±120.3 mIU/ml VS 1 583±142.5mIU/ml, p<0.05), and there were not significant difference in the serum level of E 2 and FSH and the time of Serum peak Level of E 2, FSH and LH present between two groups. The women with LPD in this study were characterized by the lower serum LH level, and were not siginificantly morphologically abnormal in follicular development.