新资源食品松花粉预防前列腺增生的研究

Study on New Food Resource “Masson Pine Pollen” on Provention of Prostatic Hypertrophy

目的:观察松花粉对前列腺增生的预防作用。方法:雄性SD大鼠24只,分为第1组(对照组),以及2、3组(安慰剂组和松花粉组,分别饲喂安慰剂和松花粉)。饲喂2w后,2、3组大鼠建立前列腺增生模型。实验结束后,取前列腺组织进行病理观察,测定性激素、微量元素锌、铜及有关抗氧化指标等。结果:松花粉组前列腺重量及前列腺细胞增殖状态均明显优于安慰剂组,其前列腺锌、铜含量最高,而肝锌含量显著低于安慰剂组;安慰剂和松花粉组血清睾酮(T)水平高于对照组,血清铜、锌含量均显著低于对照组,而血清雌二醇(E_2)水平松花粉组最低。结论:松花粉可以预防实验动物前列腺增生,其作用机理可能是通过调节体内性激素的平衡来发挥抑制前列腺增生的作用。

Objective： To study the preventive effect of Masson Pine Pollen on rats with benign prostatic hypertrophy （BPH） and its mechanism. Methods： Twenty-four SD rats were divided into 3 groups. Three groups were fed with normal diet. The group 2 and group 3 were fed with 3 starch tablets （as placebo） and 3 Masson Pine Pollen tablets per day respectively, and the group 2 and group 3 were be pair-fed with group 1. After two weeks, group 2 and group 3 were injected with testosterone propionate （4mg/kg） which was mixed with olive oil. At the same time, group 1 was injected with olive oil （lml/kg） alone. Two weeks later, the pathologic slices of prostate were observed, and the sex hormones contents, trace elements zinc, copper and antioxidantive enzymes of serum, prostate and liver were determined. Results： It showed that the prostate hyperplasia symptoms of Masson Pine Pollen group are much better than those of placebo group. Testosterone level of group 3 is lower than that of group 2 and no distinct difference from control. The estradiol level in serum of rats in group 3 is the lowest. Conclusion： Intaking Masson Pine Pollen could improve the symptoms of BPH. The preventive mechanism can regulate sex hormones balance.