Graves病所致抑郁状态的危险因素研究

Study on the risk factors of depressive state caused by Graves disease.

目的研究初诊Graves病(GD)所致抑郁状态的危险因素。方法收集我院住院及门诊的GD患者527例,对其一般资料、家庭功能、生活应激事件及抑郁情绪等情况进行调查与评定,并采用Logistic回归分析确定与抑郁状态有关的危险因素。结果GD所致抑郁状态的患病率为61.9%,男女分别为70.0%、59.2%,GD所致抑郁状态与心率(OR=11.268)、眼病(OR=1.312)、游离T3(FT3,OR=1.562)、TSH(OR=0.980)、家庭功能(OR=0.264)及生活应激事件(OR=2.159)有明显相关性。结论高龄、低收入、低文化GD人群是GD所致抑郁状态的高发人群;心率、眼病、FT3及生活应激事件是GD患者所致抑郁状态的独立危险因素;家庭功能和TSH是GD所致抑郁的保护因素。

Objective To explore the risk factors of depressive state caused by Graves＇ disease. Methods We collected data of 527 patients with Graves, disease using the common item table, the Smilkstein APGAR family function scale ,the Stress Life EventsTM ,the Zung depression Scale, and analyzed data using multinomial logistic regression to demonstrate the characteristic distribution and risk facts of depressive state in GD patients. Results 326 of 527 GD patients, （61.9%） had depressive state,at the same time,the rate of male was 70. 0% and the rate of female was 48. 7%. There were the obvious odds between heart rate, GO, the thyroid dysfunction, family function, life events and depressive state. Conclusions The heart rate, GO, FT3 and life events are risk factors for depresssive state with GD, while TSH and family function are protect factors.