摘要
在催化剂作用下,2-乙酰噻吩与过量的正丁胺反应生成乙酰噻吩-N-正丁胺,减压浓缩后直接在有机溶剂中与过量的硫反应得到N-丁基噻吩硫酰胺粗品,经浓缩、静置、过滤后在庚醇中氢氧化钠作用下发生水解,进一步酸化得到2-噻吩乙酸,总收率为46.5%。
2-Thiophene acetic acid was synthesized through the following steps.2-Acetylthiophene was condensed with an excess of n-butylamine in the presence of catalyst so as to obtain acetylthiophene-N-n-butylamine.The concentrated imine was reacted with excess sulfur in organic solvent to produce N-butylthioamide.After concentration,depositing,filtration, the thioamide was hydrolyzed by the action of NaOH in heptanol and acidificated ulteriorly to liberate 2-thiophene acetic acid.The total yield of 2-thiophene acid was 46.5%.
出处
《化学与生物工程》
CAS
2007年第4期22-23,共2页
Chemistry & Bioengineering
基金
辽宁省抚顺市科学技术计划项目(20052517)
