昆虫中肠Bt毒素受体氨肽酶N的研究进展

Research Progress in the Insect Midgut Aminopeptidase N

氨肽酶N(APN)是昆虫中肠中主要的Bt毒素受体,它与Cry毒素特异结合后,毒素插入细胞膜,在膜上形成孔洞,细胞裂解,最终导致昆虫死亡。APN的变异导致昆虫对Bt敏感性下降甚至产生抗性。就APN的结构特征、分类、APN与Cry毒素的相互作用机制以及APN与昆虫Bt抗性的关系作一综述。

Aminopeptidase N is a major kind of receptors for Bt toxins in the midgut of insects. Cry toxins bind to APN on the midgut epithelium and a porein of the toxin inserts into the membrane forming a pore. The integrity of midgut epithelia cells is destroyed and the insect dies. The mutation of APN results in insects resistance to Bt toxins.With the development of the studies on APN, it is possible to fred out some mere efficient resistance management strategies. The research progress in the aminopeptidase N receptors on the midgut epithelial membrane of susceptible insects for Bacillus thuringiensis toxins was reviewed.