几丁质合成酶抑制剂

Studies on Chitin Synthase Inhibitors

几丁质合成酶是生物合成几丁质的关键物质。几丁质是昆虫表皮和真菌细胞壁的特征成分,由于存在的特殊性而成为农药和医药研发的独特靶标。几丁质合成酶抑制剂由于具有安全、高效等特点,成为农用杀虫、杀螨、杀菌剂以及医药抗真菌药物的研发热点。本文综述了天然及人工合成的几丁质合成酶抑制剂的研究进展,并对其发展趋势进行了展望。

Chitin synthase is the important enzyme that converts UDP-GlcNAc to chitin. Chitin which absents in vertebrates and plants, is an integral structural component of insect cuticle and fungal cell wall and is a promising target of agrochemicals and drugs. For the high selectivity and safety of chitin synthase inhibitors, they are used for insecticides, fungicides and acaricides. The natural and synthesized chitin synthase inhibitors are reviewed.