糖骨康对糖尿病骨质疏松患者血清IGF-1和TGF-β1含量的影响

The Influence of Tanggukang on the Content of Serum IGF-1,TGF-β1 in Diabetic Osteoporosis

目的:观察糖骨康对糖尿病骨质疏松患者骨密度(BMD)、空腹血糖(FBG)及血清胰岛素样生长因子-1(IGF-1)、转化生长因子-β1(TGF-β1)含量的影响。方法:将139例患者随机分为2组。治疗组74例,服用中药糖骨康汤剂(由熟地黄、山茱萸、山药、锁阳、龟板、丹参、川芎组成):对照组65例,服用盖天力片。2组均连续治疗30天,治疗前后检测BMD、FBG和血清IGF-1、TGF-β1含量的变化．．结果:治疗后2组BMD和血清IGF-1、TGF-β1含量明显上升、FBG明显下降,与治疗前比较,差异有显著性或非常显著性意义(P＜0．05,P＜0．01);治疗组BMD和TGF-β1升高尤为明显,与对照组治疗后比较,差异有显著性意义(P＜0．05)。结论:糖骨康通过调节糖尿病骨质疏松患者血清IGF-1、TGF-β1含量,降低血糖,抑制骨质疏松。

Objective:To observe the influence of Tanggukang(TGK,糖骨康)on the bone mineral density(BMD),fasting blood glucose(FBG),the content of serum IGF-I and TGF-β1 of diabetic osteoporosis(DO).Meth- ods:139 cases were allocated to 2 groups randomly.The treatment group(74 cases)was treated by TGK(composed of Radix Rehmanniae Preparata,Fructus Corni,Rhizoma Dioscoreae,Herba Cynomorii,Carapax et Plastrum Testudinis, Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong),the control group was treated by oyster shell calcium tablets(盖天力片).30 days constituted the course of treatment.The BMD,FBG and the content of serum IGF-1 and TGF-β1 were examined before and after treatment.Results:After treatment, the BMD and the content of serum IGF-1 and TGF-β1 were markedly in- creased,and FBG was markedly decreased in both groups than before treatment (P＜0.05,P＜0.01),in treatment group,the BMD and TGF-β1 were in- creased obviously than that of control group(P＜0.05).Conclusion:TGK acts for regulating the content of serum IGF-I and TGF-β1,lowering the blood glucose and inhibiting the osteoporosis for DO.